STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49536.1Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: pak:HMPREF0675_5336 aminotransferase, class IV; PFAM: aminotransferase class IV; SPTR: Putative uncharacterized protein; PFAM: Aminotransferase class IV. (290 aa)    
Predicted Functional Partners:
ADU48407.1
Chorismate binding protein; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999: IPR015890; KEGG: sco:SCO1547 anthranilate synthase; PFAM: Chorismate binding-like; SPTR: Aminodeoxychorismate synthase; PFAM: chorismate binding enzyme.
  
 
 0.924
ADU46623.1
Glutamine amidotransferase of anthranilate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR000991: IPR006221: IPR006220: IPR011702: IPR 001317: IPR017926; KEGG: xce:Xcel_0017 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Para-aminobenzoate synthase component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
  
 
 0.920
ADU46860.1
COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR006390; KEGG: pfr:PFREUD_02120 dihydropteroate synthase ((2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl- diphosphate:4-am inobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase); PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Dihydropteroate synthase ((2-amino-4-hydroxy-7, 8-dihydropteridin-6-yl)methyl-diphosphate:4- aminobenzoate 2-amino-4-hydroxydihydropteridine-6- methenyltransferase); TIGRFAM: dihydropteroate synthase; manually curated; PFAM: Pterin binding enzyme; TIGRFAM: [...]
  
 
 0.920
ADU47147.1
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 
 0.920
ilvD
COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404: IPR020558: IPR000581; KEGG: nfa:nfa11740 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.690
ADU47148.1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.622
ADU47278.1
hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: kse:Ksed_21580 hydroxymethylglutaryl-CoA lyase; PFAM: pyruvate carboxyltransferase; SPTR: Putative hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like.
  
 
 0.549
ADU47615.1
4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
  
 
 0.549
ADU48339.1
hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: fre:Franean1_3719 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase; PFAM: HMGL-like.
  
 
 0.549
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.549
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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