STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49581.1TrwC relaxase; COGs: COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member; InterPro IPR014862; KEGG: xce:Xcel_0849 TrwC relaxase; PFAM: TrwC relaxase; SPTR: TrwC relaxase; PFAM: TrwC relaxase; TIGRFAM: conjugative relaxase domain, TrwC/TraI family. (1096 aa)    
Predicted Functional Partners:
ADU49059.1
ATP-dependent DNA helicase, Rep family; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121: IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1179 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: Putative ATP-dependent DNA helicase; manually curated; PFAM: HRDC domain; UvrD/REP helicase.
  
 
 0.925
ADU46564.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.840
ADU49607.1
Hypothetical protein; COGs: COG3505 Type IV secretory pathway VirD4 protein; KEGG: mlu:Mlut_00130 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: TraG/TraD family.
 
   
 0.830
ADU49596.1
Hypothetical protein; COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: mlu:Mlut_00150 hypothetical protein; SPTR: Putative uncharacterized protein.
 
   
 0.828
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 
 0.784
ADU46798.1
Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC.
   
 
 0.783
ADU49594.1
KEGG: kse:Ksed_06740 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: TrbL/VirB6 plasmid conjugal transfer protein.
  
    0.775
ADU49595.1
KEGG: kse:Ksed_06750 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.771
ADU49592.1
KEGG: xce:Xcel_0821 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.770
ADU49608.1
KEGG: xce:Xcel_0797 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.764
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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