STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gshBCOGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR011761: IPR004218; KEGG: kse:Ksed_05120 glutathione synthetase; PFAM: glutathione synthetase ATP-binding; PRIAM: Glutathione synthase; SPTR: Glutathione synthetase; PFAM: Prokaryotic glutathione synthetase, N-terminal domain; Prokaryotic glutathione synthetase, ATP-grasp domain; TIGRFAM: glutathione synthetase, prokaryotic; Belongs to the prokaryotic GSH synthase family. (332 aa)    
Predicted Functional Partners:
ADU49700.1
Protein of unknown function DUF1704; COGs: COG3930 conserved hypothetical protein; InterPro IPR012548; KEGG: paa:Paes_0605 protein of unknown function DUF1704; PFAM: protein of unknown function DUF1704; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1704); TIGRFAM: conserved hypothetical protein.
 
     0.958
ADU47005.1
Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
    
 0.913
pepA
Peptidase M17 leucyl aminopeptidase domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
   
 
 0.912
ADU47943.1
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: kfl:Kfla_5445 gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltranspeptidase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
    
 0.910
ADU48408.1
Peroxiredoxin; COGs: COG0386 Glutathione peroxidase; InterPro IPR000889; KEGG: kse:Ksed_02770 glutathione peroxidase; PFAM: glutathione peroxidase; PRIAM: Peroxiredoxin; SPTR: Glutathione peroxidase; PFAM: Glutathione peroxidase; Belongs to the glutathione peroxidase family.
     
 0.910
ADU47267.1
Membrane alanyl aminopeptidase; COGs: COG0308 Aminopeptidase N; InterPro IPR014782: IPR012778; KEGG: kse:Ksed_21360 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: Putative aminopeptidase; TIGRFAM: aminopeptidase N; PFAM: Peptidase family M1; Domain of unknown function (DUF3358); TIGRFAM: aminopeptidase N, Streptomyces lividans type.
     
 0.903
ADU47877.1
Membrane alanyl aminopeptidase; COGs: COG0308 Aminopeptidase N; InterPro IPR012778: IPR014782: IPR005829; KEGG: kse:Ksed_09020 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; PRIAM: Membrane alanyl aminopeptidase; SPTR: Aminopeptidase N; TIGRFAM: aminopeptidase N; PFAM: Domain of unknown function (DUF3358); Peptidase family M1; TIGRFAM: aminopeptidase N, Streptomyces lividans type.
     
 0.903
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.802
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.802
ADU49701.1
Maltooligosyl trehalose hydrolase; COGs: COG0296 1 4-alpha-glucan branching enzyme; InterPro IPR006589: IPR004193: IPR006047: IPR006048; KEGG: mes:Meso_2421 glycoside hydrolase family protein; PFAM: glycoside hydrolase family 13 domain protein; alpha amylase catalytic region; alpha amylase all-beta; SMART: alpha amylase catalytic sub domain; SPTR: 1,4-alpha-glucan branching enzyme; PFAM: Alpha amylase, C-terminal all-beta domain; Alpha amylase, catalytic domain; Carbohydrate-binding module 48 (Isoamylase N-terminal domain); TIGRFAM: malto-oligosyltrehalose trehalohydrolase.
       0.542
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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