STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ADU49784.1Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (162 aa)    
Predicted Functional Partners:
ADU49783.1
InterPro IPR007419; KEGG: sli:Slin_5401 molybdopterin oxidoreductase; PFAM: BFD domain protein [2Fe-2S]-binding domain protein; SPTR: Molybdopterin oxidoreductase; PFAM: BFD-like [2Fe-2S] binding domain.
  
 
 0.976
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
     
 0.917
ADU49489.1
COGs: COG2132 Putative multicopper oxidase; InterProIPR017909: IPR011707: IPR001117: IPR011706: IPR 002355; KEGG: pfr:PFREUD_19350 multicopper oxidase; PFAM: multicopper oxidase type 3; multicopper oxidase type 1; multicopper oxidase type 2; SPTR: Multicopper oxidase; PFAM: Multicopper oxidase; TIGRFAM: copper-resistance protein, CopA family.
   
 
 0.908
ADU47303.1
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932: IPR007895: IPR010822: IPR003594; KEGG: gob:Gobs_0116 multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E; MASE1 domain protein; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E (SpoIIE); MASE1.
  
  
 0.756
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
  
 0.675
ADU49785.1
KEGG: msl:Msil_1758 hypothetical protein; SPTR: Oxygenase.
       0.664
ADU49083.1
KEGG: nca:Noca_4334 hypothetical protein; SPTR: Putative uncharacterized protein.
   
  
 0.573
ADU49309.1
Response regulator receiver protein; COGs: COG0492 Thioredoxin reductase; InterPro IPR001789: IPR000103: IPR013027; KEGG: rer:RER_40230 two-component system thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Response regulator receiver domain.
   
  
 0.568
ADU47078.1
Anti-sigma-factor antagonist; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR002645: IPR003658; KEGG: kfl:Kfla_0571 anti-sigma-factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; anti-sigma F factor antagonist.
   
  
 0.558
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
     
 0.555
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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