STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49790.1COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: nca:Noca_3943 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. (415 aa)    
Predicted Functional Partners:
ADU48268.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.971
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 0.937
ADU46858.1
COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005856: IPR005859: IPR001216; KEGG: bcv:Bcav_2609 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.927
ADU47466.1
Cystathionine beta-synthase; COGs: COG0031 Cysteine synthase; InterProIPR001926: IPR000644: IPR005829: IPR001216: IPR 005857; KEGG: rha:RHA1_ro05843 cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase.
 
 0.924
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.911
ADU49309.1
Response regulator receiver protein; COGs: COG0492 Thioredoxin reductase; InterPro IPR001789: IPR000103: IPR013027; KEGG: rer:RER_40230 two-component system thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Response regulator receiver domain.
  
 
 0.906
ADU50110.1
COGs: COG0492 Thioredoxin reductase; InterPro IPR013027: IPR000103: IPR005982: IPR008255; KEGG: kse:Ksed_26940 thioredoxin-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: thioredoxin-disulfide reductase.
   
 
 0.905
ADU48833.1
Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: nca:Noca_3292 Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Putative L,L-Cystathionine gamma-Lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
  
 
0.844
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
  
 
0.841
ADU47514.1
Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: nca:Noca_0976 cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
  
 
0.838
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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