STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49831.1Protein of unknown function DUF2587; InterPro IPR019695; KEGG: kra:Krad_0259 hypothetical protein; PFAM: Protein of unknown function DUF2587; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2587). (207 aa)    
Predicted Functional Partners:
prcA
20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
  
 
 
 0.984
prcB
Proteasome endopeptidase complex, beta component; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
  
 
 
 0.960
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
  
   
 0.775
ADU49832.1
Metallophosphoesterase; InterPro IPR004843; KEGG: bfa:Bfae_11330 predicted phosphohydrolase; PFAM: metallophosphoesterase; SPTR: Putative integral membrane protein; PFAM: Calcineurin-like phosphoesterase.
       0.709
pafA
Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
  
   
 0.674
ADU48280.1
InterPro IPR004347; KEGG: kra:Krad_1871 protein of unknown function DUF245 domain protein; PFAM: protein of unknown function DUF245 domain protein; SPTR: Putative uncharacterized protein; PFAM: Pup-ligase protein; TIGRFAM: proteasome accessory factor PafA2.
  
   
 0.574
ADU48894.1
InterPro IPR002629; KEGG: tcu:Tcur_3565 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase vitamin-B12 independent; SPTR: Putative uncharacterized protein; PFAM: Cobalamin-independent synthase, Catalytic domain.
  
     0.521
ADU49829.1
COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467: IPR004358: IPR003594: IPR017205: IPR 011712; KEGG: sco:SCO1369 two component system histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; SMART: ATP-binding region ATPase domain protein; SPTR: Probable two component system histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
       0.498
ADU49830.1
Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792: IPR001789; KEGG: lxx:Lxx07500 two-component system, regulatory protein; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: LuxR family DNA-binding response regulator; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family.
       0.498
whiB
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.489
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.