STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49834.1COGs: COG2818 3-methyladenine DNA glycosylase; InterPro IPR005019; KEGG: ach:Achl_0015 DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase; PRIAM: DNA-3-methyladenine glycosylase I; SPTR: DNA-3-methyladenine glycosylase I; PFAM: Methyladenine glycosylase; TIGRFAM: DNA-3-methyladenine glycosylase I. (195 aa)    
Predicted Functional Partners:
ADU49545.1
methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
     0.788
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.590
ADU49835.1
COGs: COG2808 Transcriptional regulator; InterPro IPR018506: IPR007396: IPR011576; KEGG: cfl:Cfla_0243 FMN-binding negative transcriptional regulator; PFAM: Negative transcriptional regulator; pyridoxamine 5'-phosphate oxidase-related FMN-binding; SPTR: Transcription antitermination factor NusB; PFAM: Putative FMN-binding domain.
       0.584
ADU49833.1
Membrane-flanked domain; InterPro IPR005182; KEGG: gob:Gobs_4362 membrane-flanked domain protein; PFAM: membrane-flanked domain; SPTR: Membrane-flanked domain protein; PFAM: Bacterial membrane flanked domain.
       0.578
ADU47177.1
COGs: COG1194 A/G-specific DNA glycosylase; InterPro IPR003265: IPR003651: IPR004036; KEGG: tcu:Tcur_4471 HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; iron-sulfur cluster loop; SPTR: Putative adenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: A/G-specific adenine glycosylase.
     
 0.520
ADU49102.1
KEGG: mav:MAV_1356 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3117).
     
 0.508
mutM
DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
      
 0.463
ADU50119.1
Hypothetical protein; COGs: COG1192 ATPase involved in chromosome partitioning; KEGG: sgr:SGR_3693 putative partitioning or sporulation protein; SPTR: Putative partitioning or sporulation protein; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
      
 0.463
glyQ
COGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR006194: IPR002310: IPR002311: IPR015944; KEGG: kfl:Kfla_5824 glycyl-tRNA synthetase, beta subunit; PFAM: glycyl-tRNA synthetase alpha subunit; glycyl-tRNA synthetase beta subunit; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase, beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit; glycyl-tRNA synthetase, alpha subunit; PFAM: Glycyl-tRNA synthetase beta subunit; Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit; glycyl-tRNA synthetase, tetrameric type, alph [...]
       0.449
ADU49836.1
Phosphoesterase PA-phosphatase related protein; InterPro IPR000326; KEGG: cmi:CMM_0208 putative membrane-associated phospholipid phosphatase; PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related; SPTR: Putative uncharacterized protein; PFAM: PAP2 superfamily.
       0.443
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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