STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49868.1Heat shock protein Hsp20; COGs: COG0071 Molecular chaperone (small heat shock protein); InterPro IPR002068: IPR010916; KEGG: pac:PPA0737 18 kDa antigen 2; PFAM: heat shock protein Hsp20; SPTR: 18 kDa antigen 2; PFAM: Hsp20/alpha crystallin family; Belongs to the small heat shock protein (HSP20) family. (143 aa)    
Predicted Functional Partners:
clpB
ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
 
 
 0.843
ADU47181.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR003593: IPR001943: IPR001270: IPR004176: IPR 003959: IPR013093: IPR019489: IPR018368; KEGG: sma:SAV_4697 ATP-dependent Clp protease; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: Putative ATP-dependent Clp protease; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activitie [...]
  
 
 0.820
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.747
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.632
ADU48507.1
Putative ferredoxin FdxA; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
   
  
 0.587
groS
Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
   
  
 0.574
ADU49522.1
COGs: COG0777 Acetyl-CoA carboxylase beta subunit; InterPro IPR011762: IPR011763: IPR000438: IPR000022; KEGG: nca:Noca_4502 carboxyl transferase; PFAM: carboxyl transferase; SPTR: Carboxyl transferase; PFAM: Carboxyl transferase domain; TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit.
  
  
 0.509
ADU47114.1
COGs: COG1926 phosphoribosyltransferase; InterPro IPR000836; KEGG: art:Arth_3462 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; Dienelactone hydrolase family.
 
  
 0.504
ADU48308.1
FxsA cytoplasmic membrane protein; COGs: COG3030 Protein affecting phage T7 exclusion by the F plasmid; InterPro IPR007313; KEGG: kfl:Kfla_3598 FxsA cytoplasmic membrane protein; PFAM: FxsA cytoplasmic membrane protein; SPTR: FxsA cytoplasmic membrane protein; PFAM: FxsA cytoplasmic membrane protein.
   
    0.502
ADU49866.1
Membrane-flanked domain; COGs: COG3402 conserved hypothetical protein; InterPro IPR005182: IPR018313; KEGG: ami:Amir_1064 membrane-flanked domain protein; PFAM: membrane-flanked domain; SPTR: Membrane-flanked domain protein; PFAM: Bacterial membrane flanked domain.
       0.493
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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