STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49870.1COGs: COG1301 Na+/H+-dicarboxylate symporter; InterPro IPR001991; KEGG: sro:Sros_3870 sodium:dicarboxylate symporter; PFAM: sodium:dicarboxylate symporter; SPTR: Putative sodium:dicarboxylate symporter; PFAM: Sodium:dicarboxylate symporter family; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (462 aa)    
Predicted Functional Partners:
ADU49871.1
COGs: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; InterProIPR013656: IPR003594: IPR005467: IPR000014: IPR 004358; KEGG: scb:SCAB_28081 putative two-component sensor kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; SPTR: Putative two-component sensor kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; TIGRFAM: PAS domain S-box.
 
  
 0.863
ADU49872.1
Response regulator receiver and unknown domain protein; COGs: COG4565 Response regulator of citrate/malate metabolism; InterPro IPR001789; KEGG: gob:Gobs_2259 response regulator receiver and unknown domain protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Putative two-component system response regulator; PFAM: Response regulator receiver domain.
 
   
 0.853
ADU48157.1
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR017932: IPR000583: IPR006982: IPR002932: IPR 002489; KEGG: kfl:Kfla_3074 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Putative glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.567
ADU48984.1
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterProIPR011603: IPR001078: IPR001017: IPR005475: IPR 000897; KEGG: kra:Krad_1228 alpha-ketoglutarate decarboxylase; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain-containing protein of components of various dehydrogenase complexes; SPTR: Alpha-ketoglutarate decarboxylase; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate [...]
  
 
 0.536
ADU47034.1
COGs: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; InterPro IPR005467: IPR013767: IPR003594: IPR004358; KEGG: sco:SCO1137 two component system histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Putative two component system histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
  
 0.522
ADU49869.1
Transcriptional coactivator/pterin dehydratase; COGs: COG2154 Pterin-4a-carbinolamine dehydratase; InterPro IPR001533; KEGG: kfl:Kfla_1145 hypothetical protein; PFAM: transcriptional coactivator/pterin dehydratase; SPTR: Putative uncharacterized protein; PFAM: Pterin 4 alpha carbinolamine dehydratase.
       0.512
ADU49201.1
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.496
ADU49891.1
COGs: COG1966 Carbon starvation protein predicted membrane protein; InterPro IPR003706; KEGG: ach:Achl_0831 carbon starvation protein CstA; PFAM: carbon starvation protein CstA; SPTR: Carbon starvation protein CstA; PFAM: Carbon starvation protein CstA.
 
  
 0.478
ADU47249.1
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
  
 0.461
ADU48268.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.455
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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