STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
ADU49903.1DNA-(apurinic or apyrimidinic site) lyase; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterPro IPR012319: IPR015886: IPR000214: IPR015887; KEGG: kra:Krad_1488 formamidopyrimidine-DNA glycolase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA-binding; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; TIGRFAM: formamidopyrimidine-DNA glycosylase (fpg). (302 aa)    
Predicted Functional Partners:
ADU49904.1
ATP dependent helicase, Lhr family; COGs: COG1201 Lhr-like helicase; InterProIPR011545: IPR001650: IPR013701: IPR014021: IPR 014001; KEGG: kra:Krad_1489 DEAD/H associated domain protein; PFAM: DEAD/H associated domain protein; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: Putative ATP-dependent DNA helicase; PFAM: Helicase conserved C-terminal domain; DEAD/H associated; DEAD/DEAH box helicase.
 
  
 0.946
ADU50117.1
DNA glycosylase/AP lyase, H2TH DNA-binding protein; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterPro IPR012319: IPR015886: IPR000214: IPR015887; KEGG: mpa:MAP2284c hypothetical protein; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; SPTR: Putative uncharacterized protein; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; Zinc finger found in FPG and IleRS; Belongs to the FPG family.
  
  
 
0.927
ADU48489.1
DNA polymerase III, epsilon subunit; COGs: COG0322 Nuclease subunit of the excinuclease complex; InterPro IPR013520: IPR000305: IPR006055: IPR006054; KEGG: kra:Krad_3247 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
  
  
 0.741
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.579
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.566
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.564
rnc
RNAse III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
     
 0.552
ADU46691.1
DNA-(apurinic or apyrimidinic site) lyase; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterPro IPR012319: IPR015886: IPR000214; KEGG: sna:Snas_1400 DNA-formamidopyrimidine glycosylase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: Putative formamidopyrimidine-DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; TIGRFAM: formamidopyrimidine-DNA glycosylase (fpg); Belongs to the FPG family.
  
   
0.541
ADU49905.1
Bifunctional deaminase-reductase domain protein; COGs: COG0262 Dihydrofolate reductase; InterPro IPR002734; KEGG: rlg:Rleg_4567 bifunctional deaminase-reductase domain protein; PFAM: bifunctional deaminase-reductase domain protein; SPTR: Putative uncharacterized protein; PFAM: RibD C-terminal domain.
       0.539
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.418
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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