Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADU49912.1Ureidoglycolate lyase; COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); InterPro IPR002529; KEGG: svi:Svir_20690 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: Ureidoglycolate lyase; SPTR: Fumarylacetoacetate hydrolase domain-containing protein 2A; PFAM: Fumarylacetoacetate (FAA) hydrolase family. (287 aa)    
Predicted Functional Partners:
ADU49911.1
InterPro IPR017517; KEGG: aau:AAur_0329 mycothiol-dependent maleylpyruvate isomerase; SPTR: Putative uncharacterized protein sdgF; PFAM: MDMPI C-terminal domain; Mycothiol maleylpyruvate isomerase N-terminal domain; TIGRFAM: uncharacterized Actinobacterial protein TIGR03083.
 
  
 0.984
ADU48189.1
InterPro IPR017517; KEGG: cai:Caci_5617 mycothiol-dependent maleylpyruvate isomerase; SPTR: Putative uncharacterized protein; PFAM: Mycothiol maleylpyruvate isomerase N-terminal domain; TIGRFAM: uncharacterized Actinobacterial protein TIGR03083.
 
  
 0.924
ADU47833.1
Fumarylacetoacetate hydrolase; COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); InterPro IPR005959: IPR015377: IPR002529; KEGG: kse:Ksed_10630 fumarylacetoacetate hydrolase; PFAM: Domain of unknown function DUF1969; fumarylacetoacetate (FAA) hydrolase; PRIAM: Fumarylacetoacetase; SPTR: Putative fumarylacetoacetase; TIGRFAM: fumarylacetoacetase; PFAM: Domain of unknown function (DUF1969); Fumarylacetoacetate (FAA) hydrolase family; TIGRFAM: fumarylacetoacetase.
     
 0.904
ADU49913.1
COGs: COG3435 Gentisate 1 2-dioxygenase; InterPro IPR013096; KEGG: ctt:CtCNB1_2778 gentisate 1,2-dioxygenase; PFAM: Cupin 2 conserved barrel domain protein; SPTR: Gentisate 1,2-dioxygenase; PFAM: Cupin domain.
 
   
 0.850
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
  0.828
ADU47720.1
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR003953: IPR004112: IPR011280; KEGG: nca:Noca_3552 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; PRIAM: Succinate dehydrogenase; SPTR: Succinate dehydrogenase subunit A; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit, Bacillus subtilis subgroup.
  
 
  0.818
ADU47719.1
COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterPro IPR006058: IPR017900: IPR017896: IPR004489; KEGG: nca:Noca_3553 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; SPTR: Succinate dehydrogenase; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.
  
 
  0.811
ADU47721.1
InterPro IPR011138; KEGG: nca:Noca_3551 succinate dehydrogenase subunit C; SPTR: Succinate dehydrogenase, cytochrome b558 subunit; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family.
    
  0.805
ADU49201.1
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.803
ADU49910.1
Fumarate reductase/succinate dehydrogenase flavoprotein domain protein; COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR003953: IPR003042; KEGG: rop:ROP_15470 putative oxidoreductase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: Aromatic-ring hydroxylase; PFAM: FAD binding domain.
 
  
 0.783
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.