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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
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ADU49932.1COGs: COG0648 Endonuclease IV; InterPro IPR012307: IPR001719: IPR018246; KEGG: nca:Noca_4666 endonuclease IV; PFAM: Xylose isomerase domain-containing protein TIM barrel; SMART: AP endonuclease family 2; SPTR: Endonuclease IV; manually curated; PFAM: Xylose isomerase-like TIM barrel; TIGRFAM: apurinic endonuclease (APN1). (265 aa)    
Predicted Functional Partners:
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 
 0.844
ADU49760.1
COGs: COG0708 Exonuclease III; InterPro IPR004808: IPR000097: IPR005135; KEGG: tfu:Tfu_0258 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
    
 
 0.838
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.818
ADU47479.1
HhH-GPD family protein; InterPro IPR003265: IPR017658; KEGG: sgr:SGR_3531 hypothetical protein; PFAM: HhH-GPD family protein; SPTR: HhH-GPD family protein; TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD superfamily base excision DNA repair protein; TIGRFAM: uncharacterized HhH-GPD family protein.
 
 
 0.801
ADU47714.1
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR005135: IPR004808; KEGG: cfl:Cfla_2498 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
    
 
 0.793
ADU47802.1
Hypothetical protein; COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; KEGG: nca:Noca_2841 hypothetical protein; SPTR: Putative uncharacterized protein.
 
 
 
 0.793
ADU50023.1
ERCC4 domain protein; InterPro IPR006166; KEGG: nca:Noca_3806 ERCC4 domain-containing protein; PFAM: ERCC4 domain protein; SPTR: ERCC4 domain protein; PFAM: Lsr2.
   
 
 0.785
ADU48489.1
DNA polymerase III, epsilon subunit; COGs: COG0322 Nuclease subunit of the excinuclease complex; InterPro IPR013520: IPR000305: IPR006055: IPR006054; KEGG: kra:Krad_3247 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
 
   
 0.614
ADU47249.1
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.544
ADU48120.1
COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR018089: IPR001754: IPR011995; KEGG: kra:Krad_3000 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; PRIAM: Orotidine-5'-phosphate decarboxylase; SPTR: Orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily.
     
 0.543
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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