STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU50001.1COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310: IPR012309; KEGG: nml:Namu_0826 ATP-dependent DNA ligase; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; SPTR: DNA ligase; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region. (466 aa)    
Predicted Functional Partners:
ADU50000.1
COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755; KEGG: kse:Ksed_15620 DNA polymerase LigD, polymerase domain; PFAM: DNA primase small subunit; SPTR: DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain.
   
 0.986
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.950
ADU46564.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.893
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.852
ADU47172.1
DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755: IPR014145; KEGG: nca:Noca_1237 ATP dependent DNA ligase; PFAM: DNA primase small subunit; SPTR: DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA polymerase LigD, polymerase domain.
   
 0.830
ADU48409.1
DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755: IPR014145; KEGG: amd:AMED_4612 ATP-dependent DNA ligase; PFAM: DNA primase small subunit; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain.
   
 0.819
ADU48296.1
COGs: COG0258 5'-3' exonuclease (including N-terminal domain of PolI); InterPro IPR002421: IPR008918: IPR020046: IPR020047; KEGG: cfl:Cfla_0590 5'-3' exonuclease, N-terminal resolvase-like domain protein; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: Putative 5'-3' exonuclease; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain.
 
 0.744
ADU49999.1
InterPro IPR000537; KEGG: nml:Namu_5114 UbiA prenyltransferase; PFAM: UbiA prenyltransferase; SPTR: Putative integral membrane protein; PFAM: UbiA prenyltransferase family.
       0.666
ADU50077.1
Protein of unknown function DUF2277; COGs: COG5552 conserved hypothetical protein; InterPro IPR018735; KEGG: ach:Achl_3874 hypothetical protein; PFAM: Protein of unknown function DUF2277; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2277).
  
     0.657
ADU49550.1
PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR017078: IPR004013; KEGG: nca:Noca_1522 hypothetical protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Putative uncharacterized protein; PFAM: PHP domain.
 
   
 0.647
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.