Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADU50123.1Protein of unknown function DUF37; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (140 aa)    
Predicted Functional Partners:
ADU50124.1
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.988
ADU50122.1
Membrane protein insertase, YidC/Oxa1 family; COGs: COG0706 Preprotein translocase subunit YidC; InterPro IPR001708: IPR020001: IPR000215; KEGG: cfl:Cfla_3727 membrane protein insertase, YidC/Oxa1 family; PFAM: 60 kDa inner membrane insertion protein; SPTR: Putative inner membrane protein translocase component YidC; TIGRFAM: membrane protein insertase, YidC/Oxa1 family; PFAM: 60Kd inner membrane protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family, C-terminal domain.
  
  
 0.951
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
 
    0.811
ADU50121.1
Single-stranded nucleic acid binding R3H domain-containing protein; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: kse:Ksed_27000 predicted RNA-binding protein; PFAM: single-stranded nucleic acid binding R3H domain-containing protein; SMART: single-stranded nucleic acid binding R3H domain-containing protein; SPTR: Putative Jag-like protein; PFAM: R3H domain.
  
    0.811
secE
Protein translocase subunit secE/sec61 gamma; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
   
    0.800
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
  
    0.795
rpmH
LSU ribosomal protein L34P; InterPro IPR000271: IPR020939; KEGG: nml:Namu_5415 50S ribosomal protein L34; PFAM: ribosomal protein L34; SPTR: 50S ribosomal protein L34; TIGRFAM: ribosomal protein L34; PFAM: Ribosomal protein L34; TIGRFAM: ribosomal protein L34, bacterial type; Belongs to the bacterial ribosomal protein bL34 family.
  
  
 0.789
ADU48824.1
Methyltransferase; COGs: COG0742 N6-adenine-specific methylase; InterPro IPR004398: IPR002052; KEGG: nda:Ndas_0208 methyltransferase; PFAM: Conserved hypothetical protein CHP00095; SPTR: Methyltransferase; TIGRFAM: methyltransferase; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family.
  
    0.768
rplB
LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
    0.597
rpmF
LSU ribosomal protein L32P; InterPro IPR002677; KEGG: cfl:Cfla_2294 ribosomal protein L32; PFAM: ribosomal L32p protein; SPTR: 50S ribosomal protein L32; TIGRFAM: ribosomal protein L32; PFAM: Ribosomal L32p protein family; TIGRFAM: ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.
   
  
 0.585
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.