Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa)    
Predicted Functional Partners:
ALC98459.1
ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.970
pyrF
Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
 
 0.959
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.948
ALD00525.1
Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.932
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
     
 0.914
ALC98741.1
Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.911
ALC99491.1
HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HAD-like hydrolase superfamily.
     
  0.900
ALC99761.1
Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
    
  0.900
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.689
pyrB
Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
   
  
 0.684
Your Current Organism:
Actinomyces
NCBI taxonomy Id: 712122
Other names: A. sp. oral taxon 414, Actinomyces sp. oral taxon 414
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.