STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_00025Hypothetical protein; COG5512 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives. (167 aa)    
Predicted Functional Partners:
HolA
Hypothetical protein; COG1466 DNA polymerase III, delta subunit.
 
   
 0.838
Gnd
6-phosphogluconate dehydrogenase-like protein; COG1023 Predicted 6-phosphogluconate dehydrogenase.
     
 0.768
recF
Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
  
  
 0.767
nucS
Hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
  
   
 0.696
RAM_13235
Hypothetical protein.
  
     0.695
RAM_10660
Hypothetical protein.
  
     0.693
RAM_25375
COG0789 Predicted transcriptional regulators.
  
     0.677
RAM_13095
Hypothetical protein.
  
     0.662
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.659
RAM_00040
Hypothetical protein.
 
     0.657
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.