STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_00180COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid). (266 aa)    
Predicted Functional Partners:
RAM_00175
Peptidyl-prolyl cis-trans isomerase A (cyclophilin A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
   
   0.707
NasT
COG3707 Response regulator with putative antiterminator output domain.
      
 0.509
RAM_44260
Hypothetical protein; COG0346 Lactoylglutathione lyase and related lyases.
   
  
 0.508
RAM_06865
COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid).
      
 0.477
RAM_39595
COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid).
      
 0.477
tatB
Sec-independent translocase; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
   
 
 0.468
tatA
Sec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
   
 
 0.468
AmiA-2
N-acetylmuramoyl-L-alanine amidase; COG3409 Putative peptidoglycan-binding domain-containing protein.
  
   0.445
AmiA
COG0860 N-acetylmuramoyl-L-alanine amidase.
  
   0.441
RAM_42690
COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
  
    0.439
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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