STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (433 aa)    
Predicted Functional Partners:
HemB
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.994
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.991
RAM_02540
COG0406 Fructose-2,6-bisphosphatase.
  
    0.960
RAM_02545
Cytochrome C biogenesis protein; COG0526 Thiol-disulfide isomerase and thioredoxins.
  
  
 0.952
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.935
HemL
COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.922
RAM_24260
COG3321 Polyketide synthase modules and related proteins.
    
 0.866
RAM_18760
Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.
 
 
 0.839
RAM_18765
Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.824
RAM_27510
COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.824
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.