STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (433 aa)    
Predicted Functional Partners:
HemB
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.992
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.990
RAM_02540
COG0406 Fructose-2,6-bisphosphatase.
  
  
 0.955
RAM_02545
Cytochrome C biogenesis protein; COG0526 Thiol-disulfide isomerase and thioredoxins.
  
  
 0.939
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.925
HemL
COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.922
RAM_24260
COG3321 Polyketide synthase modules and related proteins.
    
 0.865
CysG
uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain).
 
   
 0.800
hemE
uroporphyrinogen-III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.780
HemD
uroporphyrin-III C-methyltransferase HemD; COG0007 Uroporphyrinogen-III methylase.
 
  
 0.753
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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