STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menGUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (229 aa)    
Predicted Functional Partners:
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
    
 0.922
RAM_15580
Nucleotide-diphosphate-sugar epimerase/NmrA family protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases.
     
  0.900
RAM_17555
Nucleotide-diphosphate-sugar epimerase/NmrA family protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases.
     
  0.900
WrbA
TrpR binding protein WrbA; COG0655 Multimeric flavodoxin WrbA; Belongs to the WrbA family.
     
  0.900
RAM_33405
Nucleotide-diphosphate-sugar epimerase/NmrA family protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases.
     
  0.900
RAM_02660
Electron transfer oxidoreductase; COG0644 Dehydrogenases (flavoproteins).
     
 0.681
RAM_02755
Trans-hexaprenyltranstransferase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.
 
  
 0.622
RAM_02650
Hypothetical protein.
       0.518
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
     
 0.494
UbiE-2
COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis.
  
     0.457
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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