STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RifSNADH-dependent dihydrogenase; COG0673 Predicted dehydrogenases and related proteins. (342 aa)    
Predicted Functional Partners:
RifT
NADH-dependent dihydrogenase; COG0673 Predicted dehydrogenases and related proteins.
 
     0.875
rifL
Oxidoreductase RifL; In a complex with RifK, RifL may catalyze the oxidation of UDP-glucose to UDP-3-keto-D-glucose, which would then be used by RifK to produce UDP-kanosamine. Is not able to use dTDP-glucose as substrate.
 
     0.724
RAM_03280
Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins.
  
     0.673
RAM_01050
Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins.
  
     0.667
IolD
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; COG3962 Acetolactate synthase; Belongs to the TPP enzyme family.
 
  
 0.663
RAM_27765
Oxidoreductase domain-containing protein; COG0673 Predicted dehydrogenases and related proteins.
  
     0.653
rifK
AHBA synthase; Catalyzes the dehydration and aromatization of 5-amino-5- deoxy-3-dehydroshikimate (aminoDHS) to 3-amino-5-hydroxybenzoate (AHBA), a compound that then serves as the starter unit for the assembly of a polyketide during the biosynthesis of rifamycin B and other ansamycin antibiotics. Cannot utilize 5-deoxy-5-amino-3- dehydroquinate (aminoDHQ), 5-deoxy-5-aminoshikimate (aminoSA), quinate, 3-dehydroquinate, or 3-dehydroshikimate (DHS) as substrate.
 
  
 0.639
IolB
5-deoxy-glucuronate isomerase; COG3718 Uncharacterized enzyme involved in inositol metabolism.
 
  
 0.638
IolE-2
Inosose dehydratase; COG1082 Sugar phosphate isomerases/epimerases.
 
  
 0.631
IolE
Inosose dehydratase; COG1082 Sugar phosphate isomerases/epimerases.
 
  
 0.599
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.