STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RifTNADH-dependent dihydrogenase; COG0673 Predicted dehydrogenases and related proteins. (255 aa)    
Predicted Functional Partners:
RifS
NADH-dependent dihydrogenase; COG0673 Predicted dehydrogenases and related proteins.
 
     0.875
RAM_03130
Hypothetical protein.
       0.563
RAM_29975
Xylose isomerase; COG1082 Sugar phosphate isomerases/epimerases.
 
  
 0.522
RAM_06800
COG0524 Sugar kinases, ribokinase family.
 
  
 0.516
IolD
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; COG3962 Acetolactate synthase; Belongs to the TPP enzyme family.
  
  
 0.500
GalK
COG0153 Galactokinase; Belongs to the GHMP kinase family. GalK subfamily.
 
 
 0.477
IolB
5-deoxy-glucuronate isomerase; COG3718 Uncharacterized enzyme involved in inositol metabolism.
  
  
 0.469
rifK
AHBA synthase; Catalyzes the dehydration and aromatization of 5-amino-5- deoxy-3-dehydroshikimate (aminoDHS) to 3-amino-5-hydroxybenzoate (AHBA), a compound that then serves as the starter unit for the assembly of a polyketide during the biosynthesis of rifamycin B and other ansamycin antibiotics. Cannot utilize 5-deoxy-5-amino-3- dehydroquinate (aminoDHQ), 5-deoxy-5-aminoshikimate (aminoSA), quinate, 3-dehydroquinate, or 3-dehydroshikimate (DHS) as substrate.
  
  
 0.443
RAM_03145
Hypothetical protein.
       0.442
RifA
Rifamycin polyketide synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
  
  
 0.440
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.