STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rifFN-acetyltransferase/amide synthase; Catalyzes the release of the completed linear polyketide from the rif PKS by forming an intramolecular amide bond, in this way terminating polyketide assembly and forming the macrocyclic compound proansamycin X, an intermediate in the rifamycin B biosynthesis. (260 aa)    
Predicted Functional Partners:
RifE
COG3321 Polyketide synthase modules and related proteins.
     
 0.866
rifG
Aminodehydroquinate synthase; May catalyze the conversion of 3,4-dideoxy-4-amino-D-arabino- heptulosonate 7-phosphate (aDAHP) to 5-deoxy-5-amino-3-dehydroquinate (aDHQ). Probably involved in the formation of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of rifamycin and related ansamycins. Belongs to the sugar phosphate cyclases superfamily. aDHQS family.
     
 0.781
RifH
Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family.
       0.720
RAM_03185
Hypothetical protein.
       0.714
RifC
COG3321 Polyketide synthase modules and related proteins.
 
   
 0.708
RifB
COG3321 Polyketide synthase modules and related proteins.
     
 0.676
RifD
COG3321 Polyketide synthase modules and related proteins.
 
     0.666
RifI
COG0169 Shikimate 5-dehydrogenase.
       0.660
RifA
Rifamycin polyketide synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
     
 0.627
RAM_34870
Reductase; COG2085 Predicted dinucleotide-binding enzymes.
  
   
 0.512
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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