STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_03185Hypothetical protein. (62 aa)    
Predicted Functional Partners:
rifG
Aminodehydroquinate synthase; May catalyze the conversion of 3,4-dideoxy-4-amino-D-arabino- heptulosonate 7-phosphate (aDAHP) to 5-deoxy-5-amino-3-dehydroquinate (aDHQ). Probably involved in the formation of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of rifamycin and related ansamycins. Belongs to the sugar phosphate cyclases superfamily. aDHQS family.
       0.773
RifH
Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family.
       0.773
RifE
COG3321 Polyketide synthase modules and related proteins.
       0.714
rifF
N-acetyltransferase/amide synthase; Catalyzes the release of the completed linear polyketide from the rif PKS by forming an intramolecular amide bond, in this way terminating polyketide assembly and forming the macrocyclic compound proansamycin X, an intermediate in the rifamycin B biosynthesis.
       0.714
RifI
COG0169 Shikimate 5-dehydrogenase.
       0.714
RifD
COG3321 Polyketide synthase modules and related proteins.
       0.575
rifK
AHBA synthase; Catalyzes the dehydration and aromatization of 5-amino-5- deoxy-3-dehydroshikimate (aminoDHS) to 3-amino-5-hydroxybenzoate (AHBA), a compound that then serves as the starter unit for the assembly of a polyketide during the biosynthesis of rifamycin B and other ansamycin antibiotics. Cannot utilize 5-deoxy-5-amino-3- dehydroquinate (aminoDHQ), 5-deoxy-5-aminoshikimate (aminoSA), quinate, 3-dehydroquinate, or 3-dehydroshikimate (DHS) as substrate.
       0.451
RifC
COG3321 Polyketide synthase modules and related proteins.
       0.425
RifB
COG3321 Polyketide synthase modules and related proteins.
       0.420
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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