STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RifOCOG2120 Uncharacterized proteins, LmbE homologs. (255 aa)    
Predicted Functional Partners:
mshD
Acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
  
   
 0.641
RifM
COG0637 Predicted phosphatase/phosphohexomutase.
     
 0.607
rifN
Kanosamine kinase; Involved in the biosynthesis of 3-amino-5-hydroxybenzoate (AHBA), a compound that then serves as the starter unit for the assembly of a polyketide during the biosynthesis of rifamycin B and other ansamycin antibiotics. Catalyzes only the phosphorylation of kanosamine to yield kanosamine 6-phosphate.
       0.587
rifL
Oxidoreductase RifL; In a complex with RifK, RifL may catalyze the oxidation of UDP-glucose to UDP-3-keto-D-glucose, which would then be used by RifK to produce UDP-kanosamine. Is not able to use dTDP-glucose as substrate.
  
  
 0.576
Aes-2
COG0657 Esterase/lipase.
       0.559
RAM_34970
DsbA oxidoreductase.
 
    0.543
mshA
Glycosyl transferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
 
  
 0.472
RAM_33835
Hypothetical protein.
  
   
 0.463
RAM_46710
Hypothetical protein.
  
     0.422
RAM_23745
COG0522 Ribosomal protein S4 and related proteins.
  
     0.418
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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