STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nnrDRibokinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NA [...] (479 aa)    
Predicted Functional Partners:
RAM_08770
NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.
  
 0.908
RAM_03790
ATP/GTP-binding protein; COG0802 Predicted ATPase or kinase.
  
 
 0.884
glmS
Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
 
   
 0.827
RAM_05630
COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.
  
 0.818
RAM_07850
COG0513 Superfamily II DNA and RNA helicases.
  
 0.818
RAM_10450
COG0513 Superfamily II DNA and RNA helicases.
  
 0.818
RAM_14960
4Fe-4S ferredoxin iron-sulfur binding protein; COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit.
     
 0.804
NuoF-2
COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.
   
   0.769
nnrD-2
Carbohydrate kinase family protein; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
 
 
0.765
Alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
 
    0.760
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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