STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (256 aa)    
Predicted Functional Partners:
sdhA
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 
 0.999
SdhD
COG2142 Succinate dehydrogenase, hydrophobic anchor subunit.
 
 0.999
SdhC
COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit.
 
 0.999
sdhA-2
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 
 0.991
sdhA-3
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
  
 0.982
SdhC-2
Succinate dehydrogenase cytochrome b-556 subunit.
  
 
 0.962
NuoF-2
COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.
  
 
 0.959
kgd
Alpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.
  
 
 0.954
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.938
sucC-2
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.935
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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