STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_04910Deaminase-reductase domain-containing protein; COG0262 Dihydrofolate reductase. (195 aa)    
Predicted Functional Partners:
RAM_19000
Riboflavin biosynthesis protein RibD.
 
     0.743
RAM_26165
Riboflavin biosynthesis protein; COG0262 Dihydrofolate reductase.
  
     0.675
RAM_46000
Hypothetical protein; COG0262 Dihydrofolate reductase.
  
     0.664
RAM_26730
Hypothetical protein; COG0262 Dihydrofolate reductase.
  
     0.657
RAM_37745
COG0262 Dihydrofolate reductase.
  
     0.646
RAM_23835
Hypothetical protein; COG0262 Dihydrofolate reductase.
  
     0.537
RAM_04905
Methyltransferase; COG0500 SAM-dependent methyltransferases.
       0.501
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.496
RAM_04900
COG1309 Transcriptional regulator.
       0.482
YaeR-2
Glyoxalase/bleomycin resistance protein/dioxygenase; COG0346 Lactoylglutathione lyase and related lyases.
 
    0.473
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.