STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
Experiments
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[Homology]
Score
RAM_06220Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases. (280 aa)    
Predicted Functional Partners:
RAM_06215
Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases.
     0.950
RAM_21800
Hypothetical protein; COG1392 Phosphate transport regulator (distant homolog of PhoU).
 
  
 0.913
glnE
Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]
     
 0.701
RAM_06230
Thioesterase; COG0824 Predicted thioesterase.
  
    0.655
GuaA
COG0518 GMP synthase - Glutamine amidotransferase domain.
  
    0.552
RAM_06205
Rhodanese-like protein; COG0607 Rhodanese-related sulfurtransferase.
  
  
 0.531
CysG
uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain).
  
  
 0.513
lysS
lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.451
cysC
Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family.
  
  
 0.441
GltB
Glutamate synthase (NADPH/NADH) large chain; COG0067 Glutamate synthase domain 1.
  
  
 0.417
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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