glnE protein (Amycolatopsis mediterranei) - STRING interaction network

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glnE

Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (991 aa)

Predicted Functional Partners:

GlnA

0.904

glnD

0.815

RAM_06230

0.761

GlnA2

0.747

rbpA-2

0.739

RAM_13235

0.737

GlnB

0.728

Rnd

0.726

RAM_25375

0.707

RAM_06215

0.701

Your Current Organism:

Amycolatopsis mediterranei

NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GlnA	GlnA2	RAM_06235	RAM_06190	COG0174 Glutamine synthetase.	COG0174 Glutamine synthetase.	0.700
GlnA	GlnB	RAM_06235	RAM_09850	COG0174 Glutamine synthetase.	COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	0.863
GlnA	RAM_25375	RAM_06235	RAM_25375	COG0174 Glutamine synthetase.	COG0789 Predicted transcriptional regulators.	0.424
GlnA	glnD	RAM_06235	RAM_09855	COG0174 Glutamine synthetase.	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	0.827
GlnA	glnE	RAM_06235	RAM_06225	COG0174 Glutamine synthetase.	Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]	0.904
GlnA2	GlnA	RAM_06190	RAM_06235	COG0174 Glutamine synthetase.	COG0174 Glutamine synthetase.	0.700
GlnA2	GlnB	RAM_06190	RAM_09850	COG0174 Glutamine synthetase.	COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	0.774
GlnA2	RAM_25375	RAM_06190	RAM_25375	COG0174 Glutamine synthetase.	COG0789 Predicted transcriptional regulators.	0.426
GlnA2	glnD	RAM_06190	RAM_09855	COG0174 Glutamine synthetase.	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	0.638
GlnA2	glnE	RAM_06190	RAM_06225	COG0174 Glutamine synthetase.	Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]	0.747
GlnB	GlnA	RAM_09850	RAM_06235	COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	COG0174 Glutamine synthetase.	0.863
GlnB	GlnA2	RAM_09850	RAM_06190	COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	COG0174 Glutamine synthetase.	0.774
GlnB	glnD	RAM_09850	RAM_09855	COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	0.998
GlnB	glnE	RAM_09850	RAM_06225	COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]	0.728
RAM_06215	RAM_06230	RAM_06215	RAM_06230	Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases.	Thioesterase; COG0824 Predicted thioesterase.	0.655
RAM_06215	glnE	RAM_06215	RAM_06225	Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases.	Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]	0.701
RAM_06230	RAM_06215	RAM_06230	RAM_06215	Thioesterase; COG0824 Predicted thioesterase.	Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases.	0.655
RAM_06230	glnE	RAM_06230	RAM_06225	Thioesterase; COG0824 Predicted thioesterase.	Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]	0.761
RAM_13235	RAM_25375	RAM_13235	RAM_25375	Hypothetical protein.	COG0789 Predicted transcriptional regulators.	0.773
RAM_13235	Rnd	RAM_13235	RAM_13420	Hypothetical protein.	COG0349 Ribonuclease D.	0.660

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