STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_06230Thioesterase; COG0824 Predicted thioesterase. (141 aa)    
Predicted Functional Partners:
RifB
COG3321 Polyketide synthase modules and related proteins.
  
 
 0.894
RAM_20005
Polyketide synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
  
 
 0.874
RAM_18760
Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.783
RAM_18765
Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.783
RAM_27510
COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.783
glnE
Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]
  
    0.765
RifA
Rifamycin polyketide synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
  
 
 0.659
RAM_23440
Type I polyketide synthase; COG2070 Dioxygenases related to 2-nitropropane dioxygenase.
  
 
 0.659
RAM_06215
Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases.
  
    0.655
RAM_06220
Inorganic phosphate transporter PiT family protein; COG0306 Phosphate/sulphate permeases.
  
    0.655
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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