STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_08045COG4147 Predicted symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (535 aa)    
Predicted Functional Partners:
RAM_08050
Clumping factor B; COG3162 Predicted membrane protein.
 
  
 0.984
RAM_12660
COG3162 Predicted membrane protein.
 
  
 0.935
RAM_08055
Transmembrane transport protein; COG4147 Predicted symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
 
    
0.718
RAM_08065
COG3279 Response regulator of the LytR/AlgR family.
 
     0.627
RAM_08070
Two-component system histidine kinase; COG3275 Putative regulator of cell autolysis.
 
     0.625
RAM_08060
Hypothetical protein.
       0.609
Acs-2
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
 
  
 0.504
RAM_05105
Hypothetical protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
 
  
 0.458
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
  
 0.439
RAM_08075
Hypothetical protein; COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain).
       0.430
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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