STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_08135COG3118 Thioredoxin domain-containing protein. (323 aa)    
Predicted Functional Partners:
NrdA-2
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.754
TrxB
Thioredoxin reductase; COG0784 FOG: CheY-like receiver.
  
 
 0.749
HemD
uroporphyrin-III C-methyltransferase HemD; COG0007 Uroporphyrinogen-III methylase.
  
  
 0.612
RAM_25330
Hypothetical protein.
  
    0.609
TrxB-3
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COG0492 Thioredoxin reductase.
  
 
 0.581
TrxB-4
COG0492 Thioredoxin reductase.
  
 
 0.581
RAM_08130
Hypothetical protein.
       0.552
RAM_24605
Hypothetical protein.
    
   0.515
GroE-2
Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family.
 
 
 0.508
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.493
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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