STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AceBCOG2225 Malate synthase; Belongs to the malate synthase family. (535 aa)    
Predicted Functional Partners:
AceA
COG2224 Isocitrate lyase.
 
 0.999
GltA-2
COG0372 Citrate synthase; Belongs to the citrate synthase family.
   
 0.952
GltA-3
COG0372 Citrate synthase; Belongs to the citrate synthase family.
   
 0.952
kgd
Alpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.
   
 
 0.948
GltA
COG0372 Citrate synthase.
   
 0.947
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.937
RAM_13045
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.928
Acs-2
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
   
 0.927
Acs-3
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
   
 0.927
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.927
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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