STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AceB-2COG2225 Malate synthase; Belongs to the malate synthase family. (525 aa)    
Predicted Functional Partners:
AceA
COG2224 Isocitrate lyase.
 
 0.999
GltA
COG0372 Citrate synthase.
  
 0.945
GltA-2
COG0372 Citrate synthase; Belongs to the citrate synthase family.
  
 0.945
GltA-3
COG0372 Citrate synthase; Belongs to the citrate synthase family.
  
 0.945
Acs-2
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
   
 0.939
Acs-3
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
   
 0.939
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.939
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.931
RAM_13045
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.929
AtoB
Putative acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
 0.923
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.