STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SmfDNA processing protein; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. (332 aa)    
Predicted Functional Partners:
ComE
Competence protein ComEC; COG0658 Predicted membrane metal-binding protein.
 
  
 0.908
ComM
Magnesium chelatase family protein; COG0606 Predicted ATPase with chaperone activity.
 
 0.888
RecQ-3
COG0514 Superfamily II DNA helicase.
  
 
 0.805
RAM_20890
Fused protein kinase and phosphatase containing multi-sensor domain; COG2202 FOG: PAS/PAC domain.
  
    0.777
YraN
Endonuclease; COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Belongs to the UPF0102 family.
 
  
 0.741
PilD
Leader peptidase (prepilin peptidase)/N-methyltransferase; COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases.
 
  
 0.734
topA
DNA topoisomerase I subunit omega; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus rem [...]
     
 0.694
PilD-2
Leader peptidase (prepilin peptidase)/N-methyltransferase.
  
  
 0.680
recA
Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 
 0.667
PilB
COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB.
 
  
 0.639
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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