Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family.

Aminodehydroquinate synthase; May catalyze the conversion of 3,4-dideoxy-4-amino-D-arabino- heptulosonate 7-phosphate (aDAHP) to 5-deoxy-5-amino-3-dehydroquinate (aDHQ). Probably involved in the formation of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of rifamycin and related ansamycins. Belongs to the sugar phosphate cyclases superfamily. aDHQS family.

COG0287 Prephenate dehydrogenase.

COG0077 Prephenate dehydratase.

COG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family.

Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.

COG1605 Chorismate mutase.

Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]