STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CoxACytochrome C oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (590 aa)    
Predicted Functional Partners:
CoxB
COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2.
 
 0.999
CoxC
COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3.
 
 0.999
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 0.996
QcrA
Ubiquinol-cytochrome C reductase iron-sulfur subunit; COG0723 Rieske Fe-S protein.
 
 0.967
RAM_11175
Integral membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
 
 
 0.963
NuoF-2
COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.
   
 
 0.957
QcrB-2
COG1290 Cytochrome b subunit of the bc complex.
 
 
 0.950
QcrA-2
Ubiquinol-cytochrome C reductase iron-sulfur subunit; COG0723 Rieske Fe-S protein.
 
 
 0.937
QcrB
COG1290 Cytochrome b subunit of the bc complex.
 
 
 0.936
NuoM
COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M).
  
 
 0.913
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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