STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_16915GGDEF domain-containing diguanylate cyclase; COG2199 FOG: GGDEF domain. (396 aa)    
Predicted Functional Partners:
RAM_42515
Signal transduction protein; COG2202 FOG: PAS/PAC domain.
 
 
 0.860
RAM_02995
Signal sensor protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
 
  
 0.844
RAM_22165
COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
 
 
 0.826
RAM_14510
Hypothetical protein; COG2200 FOG: EAL domain.
 
  
 0.767
RAM_20890
Fused protein kinase and phosphatase containing multi-sensor domain; COG2202 FOG: PAS/PAC domain.
  
 
 0.730
RAM_01960
Signal transduction protein containing EAL, PAS and GGDEF domain; COG2202 FOG: PAS/PAC domain.
 
 
0.636
RAM_14610
Diguanylate cyclase/phosphodiesterase; COG2199 FOG: GGDEF domain.
 
 
0.598
RAM_30220
Two-component system sensor kinase; COG2202 FOG: PAS/PAC domain.
  
 
 0.568
RAM_10000
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.551
RAM_16910
Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.
 
     0.530
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.