STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_17080Hypothetical protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. (363 aa)    
Predicted Functional Partners:
HscA
COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.
 
 0.926
DnaK-3
COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.
 
 0.876
DnaK
COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.
 
 0.871
DnaK-2
Molecular chaperone DnaK; COG4249 Uncharacterized protein containing caspase domain; Belongs to the heat shock protein 70 family.
 
 0.853
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.852
NuoF-2
COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.
  
 
 0.849
RAM_20005
Polyketide synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
  
 
 0.826
RAM_47470
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...]
 
 
 0.821
htpG
Heat shock protein 90; Molecular chaperone. Has ATPase activity.
  
 0.809
RAM_34185
Probable chaperone protein; COG0326 Molecular chaperone, HSP90 family.
  
 0.809
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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