STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_17285COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain). (500 aa)    
Predicted Functional Partners:
RAM_01350
COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain).
 
  
0.920
RAM_07980
COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain).
 
  
0.919
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.919
Pyk
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.912
RelA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.910
cpdA
Phosphohydrolase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
     
 0.905
RAM_17050
RelA/SpoT domain-containing protein; COG2357 Uncharacterized protein conserved in bacteria.
     
 0.902
RAM_07475
Two-component system sensor kinase; COG0642 Signal transduction histidine kinase.
  
 0.864
RAM_23045
Two-component system sensor kinase; COG2770 FOG: HAMP domain.
  
 
 0.855
RAM_34820
Two-component system sensor kinase; COG2770 FOG: HAMP domain.
  
 
 0.845
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.