STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_17285COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain). (500 aa)    
Predicted Functional Partners:
RAM_01960
Signal transduction protein containing EAL, PAS and GGDEF domain; COG2202 FOG: PAS/PAC domain.
 
 
 0.867
RAM_20890
Fused protein kinase and phosphatase containing multi-sensor domain; COG2202 FOG: PAS/PAC domain.
 
 
 0.866
RAM_23045
Two-component system sensor kinase; COG2770 FOG: HAMP domain.
  
 
 0.841
RAM_07475
Two-component system sensor kinase; COG0642 Signal transduction histidine kinase.
  
 0.814
RAM_34820
Two-component system sensor kinase; COG2770 FOG: HAMP domain.
  
 
 0.814
RAM_30220
Two-component system sensor kinase; COG2202 FOG: PAS/PAC domain.
  
 
 0.799
RAM_17280
COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
     
 0.737
CheR-2
COG1352 Methylase of chemotaxis methyl-accepting proteins.
     
 0.666
Fpr-2
ferredoxin--NADP+ reductase; COG1146 Ferredoxin.
 
   
 0.635
Fnr
CRP/FNR family transcriptional regulator; COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases.
 
 0.569
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.