STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HypFCOG0068 Hydrogenase maturation factor. (718 aa)    
Predicted Functional Partners:
HypE
Hydrogenase expression/formation protein HypE; COG0309 Hydrogenase maturation factor.
 
 
 0.985
RAM_19250
COG1740 Ni,Fe-hydrogenase I small subunit.
 
 
 
 0.926
HypD
Hydrogenase isoenzymes formation protein HypD; COG0409 Hydrogenase maturation factor.
 
  
 0.918
HypC
Hydrogenase assembly chaperone HypC/HupF; COG0298 Hydrogenase maturation factor.
 
 
 0.908
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.884
HypB
Hydrogenase nickel incorporation protein HypB; COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase.
 
   
 0.869
RAM_19295
Peptidase M52/hydrogen uptake protein; COG0680 Ni,Fe-hydrogenase maturation factor.
 
   
 0.868
RAM_19320
COG0374 Ni,Fe-hydrogenase I large subunit.
 
 
 
 0.826
RAM_19325
COG1740 Ni,Fe-hydrogenase I small subunit.
 
 
 
 0.776
RAM_19255
Thioredoxin-like protein.
 
     0.747
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.