STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_19825Phthalate 4,5-dioxygenase; COG2258 Uncharacterized protein conserved in bacteria. (558 aa)    
Predicted Functional Partners:
NuoF-2
COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.
  
 
 0.962
IscS
COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
 0.857
NifU
Nitrogen fixation protein NifU; COG0822 NifU homolog involved in Fe-S cluster formation.
  
 0.840
MoaB
Molybdenum cofactor biosynthesis protein B; COG0521 Molybdopterin biosynthesis enzymes.
   
 
 0.830
Fpr-2
ferredoxin--NADP+ reductase; COG1146 Ferredoxin.
   
 0.788
PaaE-2
Phenylacetic acid degradation oxidoreductase; COG3239 Fatty acid desaturase.
 
  
0.787
nuoI
NADH dehydrogenase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
 
 0.740
RAM_19820
Hypothetical protein.
       0.686
nuoD
NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family.
  
 
 0.681
FadH
NADPH-dependent 2,4-dienoyl-CoA reductase; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family.
  
 0.674
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.