STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AgaSCOG2222 Predicted phosphosugar isomerases. (376 aa)    
Predicted Functional Partners:
RAM_19970
COG2971 Predicted N-acetylglucosamine kinase.
 
   
 0.949
pfp
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
    
 0.917
ManZ
Mannose/fructose-specific IIC/D component of PTS system; COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC.
 
  
 0.904
ManX
Mannose-specific IIB subunit of PTS system; COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB.
 
  
 0.758
AgaR
COG1349 Transcriptional regulators of sugar metabolism.
 
   
 0.744
NagA
COG1820 N-acetylglucosamine-6-phosphate deacetylase.
 
  
 0.696
ManX-2
Mannose/sorbose-specific IIA subunit of PTS system; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA.
 
  
 0.671
CutC
COG3142 Uncharacterized protein involved in copper resistance; Belongs to the CutC family.
 
     0.644
LacC
Tagatose 6-phosphate kinase; COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB).
 
   
 0.513
RsmB
Ribosomal RNA small subunit methyltransferase B; COG0144 tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
   
    0.510
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.