STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BetACOG2303 Choline dehydrogenase and related flavoproteins. (541 aa)    
Predicted Functional Partners:
gabD2-2
Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.
  
  
 0.803
FolA
COG0262 Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
  
    0.459
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.455
QcrC
COG2010 Cytochrome c, mono- and diheme variants.
   
 
 0.434
RAM_03130
Hypothetical protein.
    
 0.425
RAM_09065
Hypothetical protein; COG2319 FOG: WD40 repeat.
    
 0.425
RAM_11750
Hypothetical protein.
    
 0.425
RAM_14815
Hypothetical protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains.
    
 0.425
RAM_18160
Hypothetical protein; COG2319 FOG: WD40 repeat.
    
 0.425
RAM_18355
Hypothetical protein; COG2319 FOG: WD40 repeat.
    
 0.425
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.