STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MhpE4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (351 aa)    
Predicted Functional Partners:
MhpF
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
 0.999
RAM_44255
COG3971 2-keto-4-pentenoate hydratase.
 
 
 0.985
RAM_44250
Decarboxylase; COG3971 2-keto-4-pentenoate hydratase.
 
  
 0.857
RAM_07865
Hydratase/decarboxylase; COG3971 2-keto-4-pentenoate hydratase.
 
  
 0.849
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.723
RAM_36900
Metapyrocatechase (catechol 2,3-dioxygenase); COG0346 Lactoylglutathione lyase and related lyases.
 
   
 0.690
RAM_21220
COG0439 Biotin carboxylase.
  
 
 0.687
RAM_21500
Hypothetical protein.
       0.658
leuD
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
  
 0.647
MhpC-2
2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
 
 
 0.644
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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