STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PilDLeader peptidase (prepilin peptidase)/N-methyltransferase; COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases. (259 aa)    
Predicted Functional Partners:
PilC
Type IV pilus assembly protein PilC; COG1459 Type II secretory pathway, component PulF.
 
  
 0.914
PilB
COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB.
 
 
 0.900
PilT
COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT.
 
   
 0.864
ComE
Competence protein ComEC; COG0658 Predicted membrane metal-binding protein.
 
  
 0.792
Smf
DNA processing protein; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake.
 
  
 0.696
RAM_22675
Type IV pilus assembly protein PilA.
 
   
 0.669
aroE
COG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family.
  
  
 0.653
coaE
dephospho-CoA kinase/protein folding accessory domain-containing protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.513
RAM_22655
Hypothetical protein.
  
  
 0.503
RAM_22650
Hypothetical protein.
  
  
 0.502
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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