STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_23250COG0477 Permeases of the major facilitator superfamily. (432 aa)    
Predicted Functional Partners:
RAM_23285
COG1042 Acyl-CoA synthetase (NDP forming).
 
     0.728
IlvB-5
Acetolactate synthase I/II/III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family.
 
     0.698
ApbA
2-dehydropantoate 2-reductase; COG1893 Ketopantoate reductase.
 
     0.696
frc
Formyl-coenzyme A transferase; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate; Belongs to the CoA-transferase III family. Frc subfamily.
 
     0.626
RAM_23295
COG1802 Transcriptional regulators.
 
     0.594
fdhD
Formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.
       0.537
RAM_34535
Integral membrane transporter; COG0477 Permeases of the major facilitator superfamily.
  
    0.508
RAM_12905
Hypothetical protein.
  
     0.500
RAM_22000
Hypothetical protein.
  
     0.496
ApbA-2
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
 
     0.427
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.