STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAM_23260COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (288 aa)    
Predicted Functional Partners:
sucC-2
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.780
sucD-2
succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
    0.776
RAM_35710
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.772
RAM_37190
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.771
RAM_05405
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.767
RAM_30100
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.764
RAM_21185
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.719
RAM_45620
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.710
RAM_30105
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.429
RAM_01415
COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.425
Your Current Organism:
Amycolatopsis mediterranei
NCBI taxonomy Id: 713604
Other names: A. mediterranei S699, Amycolatopsis mediterranei S699, Amycolatopsis mediterranei str. S699, Amycolatopsis mediterranei strain S699
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.