STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
craTranscriptional regulator; Binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)    
Predicted Functional Partners:
AMQ94525.1
Bifunctional PTS fructose transporter subunit IIA/HPr protein; Phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.691
AMQ94436.1
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.531
ptsH
PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.483
AMQ93894.1
Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.478
AMQ94523.1
PTS fructose transporter subunit IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.470
adhE
Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
    
 
 0.452
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
    
   0.451
fruK
1-phosphofructokinase; Converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family.
 
   
 0.417
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.