| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMQ94525.1 | purR | ACT75_08325 | ACT75_01165 | Bifunctional PTS fructose transporter subunit IIA/HPr protein; Phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.593 |
| AMQ94525.1 | pyk | ACT75_08325 | ACT75_11365 | Bifunctional PTS fructose transporter subunit IIA/HPr protein; Phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.423 |
| AMQ94542.1 | apt | ACT75_08410 | ACT75_00585 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.618 |
| AMQ94542.1 | purR | ACT75_08410 | ACT75_01165 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.630 |
| apt | AMQ94542.1 | ACT75_00585 | ACT75_08410 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.618 |
| apt | deoD | ACT75_00585 | ACT75_07510 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.965 |
| apt | purR | ACT75_00585 | ACT75_01165 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.630 |
| deoD | apt | ACT75_07510 | ACT75_00585 | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.965 |
| deoD | purR | ACT75_07510 | ACT75_01165 | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.691 |
| deoD | zwf | ACT75_07510 | ACT75_04150 | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.553 |
| eno | idnK | ACT75_05150 | ACT75_10100 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.587 |
| eno | purR | ACT75_05150 | ACT75_01165 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.560 |
| eno | pyk | ACT75_05150 | ACT75_11365 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.989 |
| eno | zwf | ACT75_05150 | ACT75_04150 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.929 |
| folD | purR | ACT75_06255 | ACT75_01165 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.715 |
| idnK | eno | ACT75_10100 | ACT75_05150 | Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 0.587 |
| idnK | purR | ACT75_10100 | ACT75_01165 | Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.546 |
| idnK | pyk | ACT75_10100 | ACT75_11365 | Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.455 |
| idnK | zwf | ACT75_10100 | ACT75_04150 | Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.632 |
| purR | AMQ94525.1 | ACT75_01165 | ACT75_08325 | Transcriptional regulator; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Bifunctional PTS fructose transporter subunit IIA/HPr protein; Phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.593 |